I-Hangzhou-New-Test Yethula I-Epoch-making Pet Diagnostic Product Umkhiqizo Omusha Omusha - Umsebenzi Wezinso Ze-Canine ne-Feline 3-in-1 Combo Test Kit
I-Hangzhou New-Test Biotechnology Co., Ltd. imemezele ngokusemthethweni ukwethulwa kwemikhiqizo emibili emisha yokuxilonga izilwane ezifuywayo emakethe yomhlaba wonke yokuxilonga izifo ezifuywayo: iCanine/Feline renal function Triple Test Kit (Creatinine/SDMA/CysC Triple Test) (Fig. 1 and Fig. 2), okuletha isixazululo esisha nesinembayo ekuxilongweni kwempilo yezilwane ezifuywayo kanye nokwelashwa.
Umfanekiso 1 Ikhithi yokuhlola yeCanine ephindwe kathathu Umfanekiso 2 Ikhithi yokuhlola ye-Feline renal kathathu
Ngo-Okthoba 2022, i-New-Test Biotechnology Co., Ltd. yaba ngeyokuqala ukwethula i-multichannel multi-channel multiplex fluorescence immunoassay analyzer, i-NTIMM4 (isizukulwane sesithathu, bheka uMdwebo 3), kwathi ngo-2024, i-multi-channel multiplex immunofluorescence entsha. i-analyzer, i-NTIMM2 (isizukulwane sesine, bheka Umfanekiso 4). Umsebenzi wakamuva we-canine/feline renal 3-in-1 combo test kit uhambisana nawo womabili amamodeli.
Umfanekiso 3 NTIMM4 Umfanekiso 4 NTIMM2
Isebenza ngokukhethekile ocwaningweni nasekuthuthukisweni kwama-molecule amancane iminyaka eyisithupha, kwethulwa imikhiqizo emisha.
Ukunemba kokutholwa kwe-molecule encane bekuhlale kuyinselele ukuyinqoba emkhakheni wokuhlolwa kwe-POCT, futhi kuphinde kube isiqondiso socwaningo nentuthuko i-Nest-Test Bio enikezelwe kukho kusukela yasungulwa eminyakeni engaphezu kwengu-6 edlule. Izici ezingokomzimba zokucisha kanye nokubola kwezinto zendabuko ze-fluorescent zithinta ngokuqondile ukunemba kwemiphumela yokutholwa kwe-molecule encane. Ubuchwepheshe bokulebula i-nanocrystal obungavamile emhlabeni, isizukulwane sesine sama-nanomaterials e-fluorescent athuthukiswe yi-New-Test, saziwa njengama-nanomaterials e-fluorescent azinzile emakethe, anenzuzo yokunqoba izici zomzimba zokucisha ukukhanya. Ihlanganiswe neminyaka eminingana yokusebenza kahle okuqhubekayo kwenqubo, ekugcineni isixazulule inkinga yomhlaba wonke yokunemba okungalungile ekuhlolweni kwe-molecule encane ye-POCT. Ukuphusha kokuqala yikhithi yokuhlola ukusebenza kwezinso kathathu. Iqinisekisa ukunemba nokuzinza kwama-molecule amabili amancane (i-creatinine ne-SDMA) ama-reagents okutholwa phakathi nesikhathi sokuqinisekisa seminyaka engu-2.
“Ukuhlola okukodwa nakho kuyatholakala, kungani-ke kwakhiwa unxantathu wokusebenza kwezinso”——Isendlalelo sokukhula konxantathu wokusebenza kwezinso
Njengamanje, izinkomba ezivamile zokusebenza kwezinso okungavamile ezinjeni nasemakati zihlanganisa i-creatinine (CREA) ne-urea nitrogen ku-biochemistry; I-CysC (cystatin C) kanye ne-symmetric dimethylarginine (SDMA) ezinkomba zokuzivikela komzimba, njll. Njengamanje, kukholelwa ukuthi zonke izinkomba ezishiwo ngenhla zihlungwa nge-glomerulus. Lapho izinga lokuhlunga kwe-glomerular lehla ngenxa yokulimala kwezinso, lezi zinkomba zizonqwabelana egazini futhi zande ekugxiliseni ingqondo, ngaleyo ndlela zibonise izinga lokungasebenzi kahle kwezinso. Uhlelo lokugreda lwe-International Society for Research in Kidney Diseases (IRIS) luhlukanisa ukukhubazeka kwezinso emakati kube amabanga amane ngokusekelwe enanini le-creatinine (iBanga I, elivamile noma elimnene: <1.6 mg/dL; Ibanga II, elimaphakathi: 1.6-2.8 mg /dL; IBanga lesi-III, elinzima: 2.8-5.0 mg/dL; mg/dL).
Ukukhubazeka kwezinso ezinjeni kuhlukaniswe ngezigaba ezine (iBanga I, elivamile noma elincane: <1.4 mg/dL: IBanga II, elimaphakathi: 1.4-2.0 mg/dL: IBanga le-III, elinzima: 2.0-4.0 mg/dL: IBanga lesi-IV, kanye nesigaba sokugcina: >4.0 mg/dL). Kodwa-ke, ngenxa yokuzwela okulinganiselwe kwe-creatinine ekuqaleni kwesifo sezinso esingamahlalakhona (CKD), enye inkomba yangaphambili yokuhlunga umsebenzi we-nephron, i-“symmetric dimethylarginine (SDMA)”, yasetshenziswa. Ngokusho kwedatha, i-SDMA ingakhombisa okungavamile ku-25-40% wokukhubazeka kwezinso, kuyilapho i-creatinine ivame ukubhekwa njengengavamile ku-75% wokukhubazeka.
I-CysC (i-cystatin C) iyi-cysteine protease inhibitor, isisindo esiphansi samangqamuzana (13.3 kD), amaprotheni ayisisekelo angenawo glycosylated. Ingenye yezimpawu ezisetshenziswa kakhulu zokusebenza kwezinso zakuqala emithini yabantu. Njenge-creatinine ne-SDMA, ihlungwa nge-glomerulus, kodwa ihluke ku-creatinine ne-SDMA ngokuthi i-metabolism yayo ayisebenzisi umgudu womchamo, kodwa icishe igaywe ngokuphelele ngokumuncwa kabusha ngamashubhu ezinso. Yilo mehluko ocashile kodwa obalulekile akuzange kuqashelwe ngaphambili, okuholela izazi eziningi, ochwepheshe kanye nezincwadi eziphethweni ezimbili ezihlukene mayelana nokulimala okungapheli kwezinso emakati: abanye bakholelwa ukuthi i-CysC umaka wangaphambi kwesikhathi wokulimala kwezinso okungamahlalakhona okungasetshenziswa kuzo zombili izinja namakati, kuyilapho abanye bakholelwa ukuthi i-CysC ihlotshaniswa kahle ngokusesilinganisweni ku-canine CKD, kodwa kabi emakatini.
Kungani kuneziphetho ezimbili eziphambene ezivela “enkomba yokusebenza kokuhlunga kweglomerular”?
Isizathu yi-Anuria, okuyisimo esivame kakhulu emakatini kunezinye izinhlobo, ikakhulukazi kumakati angamaduna. Eminye idatha ibonisa ukuthi izehlakalo ze-Anuria emakati abesilisa ziphakeme kakhulu njenge-68.6%, futhi i-Anuria izoholela ngokuqondile ekuvinjweni kokukhishwa kwe-creatinine, i-urea nitrogen yegazi kanye ne-SDMA. Umzimba uhlale uhlanganisa futhi ukhiqiza i-creatinine entsha, i-urea nitrogen yegazi ne-SDMA, lapho ithola zonke izinkomba ezintathu egazini ngalesi sikhathi, kuzoba nokwanda okubukhali noma ngisho nokuqhuma kwezinkomba kungakhathaliseki ukuthi i-glomerulus ilimele ngempela.
I-CysC inenani layo eliyingqayizivele ngalesi sikhathi, nakuba le nkomba iwukuhlunga kwe-glomerular, ayihlanganiswa nomchamo, idlula i-tubular ukuze ifakwe kabusha. Uma kwenzeka i-Anuria kodwa ukusebenza kwezinso kuyinto evamile, inkomba ye-CysC isengagcinwa isezingeni elivamile. Kuphela uma kwenzeka umonakalo we-glomerulus noma we-tubular, inkomba ye-CysC izokhushulwa ibe engavamile. Ngakho-ke, ukutholwa kwazo zontathu izinkomba kungenza ukuxilongwa okunembile futhi kunikeze ukwelashwa okuhambisanayo ngokushesha nangempumelelo.
Amakhithi okuhlola okusebenza kwezinso okuhlola okusha oku-3-in-1 anikeza ukubaluleka okusha komtholampilo ekutholweni kokulimala kwezinso ezinjeni nasemakati!
Ichaza imigomo futhi ihlanganiswe nezici zezinkomba, ikhithi yokuhlola yokusebenza kwezinso Yokuhlola Okusha engu-3-in-1 yazalwa inokubaluleka okubalulekile komtholampilo ezinjeni namakati (ikakhulukazi amakati) ne-Anuria:
Umaka wokuhlola umsebenzi wezinso Omusha wokuhlola 3-in-1 usetshenziselwa ukuhlukanisa ukuthi ingabe kukhona ukulimala kwangempela kokusebenza kwezinso esimweni se-Anuria noma okuholela ekuvimbeni ukuphakama kwezinkomba ngenxa ye-Anuria. Ukulimala kwangempela kokusebenza kwezinso kudinga kuphela i-catheterization yomchamo kanye nokunakekelwa okuhlobene, futhi ukubikezela ngokuvamile kuba ngcono. Ukuphakama kokuvinjelwa kwama-index akudingi nje kuphela i-catheterization yomchamo kanye nokwelashwa okulwa nokuvuvukala, kodwa futhi nokwelashwa okuhlobene nesifo sezinso, futhi ukubikezela kuyinkinga kakhulu, futhi kungenzeka kakhulu ukuthi kuphenduke isifo sezinso esingamahlalakhona.
Ngezansi kunedatha yekhithi yokuhlola ye-New-Test renal 3-in-1 ye-Anuria (ukulimala kwezinso okungelona kwangempela) kanye nokulimala kwezinso kwe-Anuria + ezimweni zocwaningo lomtholampilo Lokuhlola Okusha:
| Ukutholwa kwe-Anuria Umaka wokusebenza kwezinso Wokuhlola Okusha 3-in-1 amakhithi okuhlola | Iphrojekthi | Umphumela | Umphumela |
| I-Creatinine | + | + | |
| I-SDMA | + | + | |
| CysC | + | - | |
| Isiphetho | I-Anuria ibangele ukulimala kwezinso | Isigaba sokuqala se-Anuria kanye nokulimala kwezinso noma i-Anuria engakafinyeleli ekulimaleni kwezinso |
Ngezansi ingxenye yedatha yomtholampilo evamile kanye nencazelo yecala lomsebenzi we-renal wokuhlola 3-in-1:
| Ikati | Umlando Wezokwelapha | Uphawu Lomtholampilo | I-CysC(mg/L) | I-SDHA (ug/dL) | I-CR(mg/dL) | Isiphetho |
| 2024090902 | I-cystitis/Ukulimala kwezinso okukhulu | Isimo sengqondo esibi, Ukuphelelwa ukudla, Inkomba ye-renal engavamile, i-Anuria (Ukwehluleka kwezinso okungapheli, i-anuria) | 1.09 | 86.47 | 8.18 | Ukulimala kwezinso nge-Anuria |
| 2024091201 | / | Isimo sengqondo esibi, i-Anuria, Ukungasebenzi kahle kwezinso | 0.51 | 27.44 | 8.21 | Akukho ukulimala kwezinso nge-Anuria/Isigaba sokuqala |
| 2024092702 | / | I-Anuria | 0.31 | >100.00 | 9.04 | Akukho ukulimala kwezinso nge-Anuria/Isigaba sokuqala |
| 2024103101 | / | I-Anuria | 0.3 | 14.11 | 6.52 | Akukho ukulimala kwezinso nge-Anuria/Isigaba sokuqala |
| 2024112712 | I-Anuria | 0.5 | >100.00 | 8.85 | Akukho ukulimala kwezinso nge-Anuria/Isigaba sokuqala | |
| 2024112601 | I-Dysuria/Anuria | 0.43 | >100.00 | 9.06 | Akukho ukulimala kwezinso nge-Anuria/Isigaba sokuqala | |
| 0.47 | >100.00 | 878 | Akukho ukulimala kwezinso nge-Anuria/Isigaba sokuqala | |||
| 2024112712 | / | I-Anuria | 0.54 | 94.03 | 8.64 | Akukho ukulimala kwezinso nge-Anuria/Isigaba sokuqala |
Esimweni se-Anuria, ngenxa yomehluko endleleni ye-metabolic yangaphakathi yenkomba ngayinye, kuzoba nomphumela wokuhluka okukhulu kwenkomba efanayo yokuhlunga umsebenzi wezinso. Ngakho-ke, ukuhlukaniswa okuvamile kokulimala kwezinso kwe-creatinine noma i-SDMA akusasebenzi, futhi isiphetho somtholampilo esiseduze singatholakala kuphela ngokuhlanganisa ukuhlaziywa kwesinye inkomba "CysC". Kutuswa ukuthi amalabhorethri (izibhedlela) asungule izindinganiso zangaphakathi ezisuselwe kokuhlangenwe nakho komtholampilo, ukuze kuhlolwe ukubaluleka komtholampilo okwengeziwe nokusha.
Ekugcineni, i-New-Test Biotech inethemba lokuthi lesi sihloko sizokhipha isitini ukuze sihehe i-jade, futhi sithemba ukuthi abakhiqizi abaningi baseShayina bemithi yezilwane kanye ne-diagnostic reagent bazothuthukisa imikhiqizo ebaluleke kakhulu emtholampilo futhi basize odokotela bezilwane abaningi basekhaya ukuba bafinyelele izinga eliphezulu umhlaba!
Isithasiselo: Ukwamukelwa Kwesicelo Selungelo Lobunikazi Sokuvikelwa Kwempahla Yengqondo
Isikhathi sokuthumela: Jan-22-2025
