I-Hangzhou New-Test Biotechnology Co, Ltd.Kumemezele ngokusemthethweni ukwethulwa kwama-epoch amabili - okwenza imikhiqizo emisha yokuxilonga yezilwane zasekhaya eMakethe ye-Immuno ye-Immuno ye-Immuno Okuletha ikhambi elisha nelinembayo lokuthola izilwane zasekhaya kanye nokwelashwa.
Umdwebo we-1 Canine Renal Funct Ty Terp Test Kit
Umdwebo 2 Feline Renal Function Triple Test Kit
Ngo-Okthoba 2022, i-biotechnology entsha ye-biotechnology Co, Ltd.Ngabe owokuqala waqala ukwethula i-Multiplex Fluorence Analyzer ye-Multiplex Fluorence Imnterzer, NTIMM4 (Isizukulwane sesithathu, bheka umfanekiso 3), futhi ngo-2024, isiteshi esisha se-Imunoflurescence Analyzer, i-NTIMM2 (isizukulwane sesine, bheka umfanekiso 4). Ikhithi ye-canine / feline renal yokuhlola kathathu ehambelana kathathu iyahambelana nawo womabili amamodeli.
Umdwebo 3 Ntimm4
Umdwebo 4 Ntimm2
Ngokukhethekile ku-molecule encane yokucwaninga kanye nokuthuthukiswa kweminyaka eyisithupha, kwethulwa imikhiqizo emisha.
Ukunemba kokutholwa kwama-molecule amancane bekulokhu kuyinselele ukunqoba emkhakheni wokuhlolwa kwe-poct, futhi kuwukuqondiswa kokucwaninga nentuthuko ukuthi i-Edte-Test Bio inikezelwe kuyo kusukela eminyakeni engaphezu kwengu-6 eyedlule. Izici ezigundayo ezihlanzekile nezinkomba zezinto zokwenziwa zendabuko ze-fluorescent zithinta ngokuqondile ukunemba kwemiphumela emincane yokutholwa kwama-molecule. Ubuchwepheshe be-Rare-Earth Nanocrystal Rechnion, isizukulwane sesine se-fluorescent nanomatadium athuthukiswe ngovivinyo olusha, luyaziwa njenge-fluorescent nama-nanomatadium ama-fluorescent kakhulu emakethe, okunenzuzo yokunqoba izici zomzimba zokucima phansi. Kuhlanganiswe neminyaka eminingana yokwenza kahle kwenqubo, ekugcineni kuxazulule inkinga yomhlaba wonke yokunemba ngokunemba kwe-poct smolekyuli ezincane. I-push yokuqala yikhithi yezinso kathathu test. Iqinisekisa ukunemba nokuqina kwama-molecule amabili ama-molecule amabili (Creatinine & SDMA) reagents afinyelela esikhathini sokuvunyelwa kweminyaka engu-2.
"Ukuhlolwa okukodwa kuyatholakala, ngakho-ke kungani kuthuthukisa umsebenzi we-renal triad"- Invetbugn of ukuthuthukiswa komsebenzi we-renal triad
Njengamanje, izinkomba ezijwayelekile zomsebenzi wezinso ezingejwayelekile ezinjeni nasemakati zifaka i-Creatinine (Crea) kanye ne-Urea nitrogen e-Biochemistry; I-CYSC (Cystatin C) ne-Symmetric Dimethylarginine (SDMA) kwizinkomba zokuvinjwa kwama-immunity, njll. Okwamanje, kuvame ukukholelwa ukuthi zonke izinkomba ezingenhla - Izinkomba ezishiwo zihlungwa nge-glomerulus. Lapho izinga lokuhlunga le-glomerur lincipha ngenxa yokulimala kwezinso, lezi zinkomba zizoqongelela egazini futhi zikhule ngokuhlushwa, ngaleyo ndlela zibonisa izinga lokuvuselela - ukulimazeka komsebenzi. Umphakathi wamazwe omhlaba wokucwaninga ezinkingeni zezinso (i-IRIS) Ukuhlukaniswa kwezinkinga zamakati kumakati amabanga asuselwa kunani le-creats (iBanga I, i-DL; <1.6 mg / dl; / dl; grade III, kakhudlwana: 2.8-5.0 mg / dl; kanye nebanga i-IV, End-Stage:> 5.0 mg / dl).
Ukulimazeka kwe-renal ezinjeni kuhlukaniswe kumabanga amane (iBanga I, Imnene noma imnene: <1.4 mg / DL: I-GL: I-GLS III, i-GL: 2.0-4.0 mg / DL IV, kanye ne-End-Stage:> 4.0 MG / DL). Kodwa-ke, ngenxa yokuzwela okulinganiselwe kwe-Creatine Esekuqaleni Isifo Sezinso (CKD), enye inkomba yangaphambilini ye-Nephron funct Filtration, "Symmetric DimethylarGinene (SDMA)", yasetshenziswa. Ngokusho kwemininingwane, i-SDMA ingakhombisa ukungahambi kahle ngo-25- 40% wokulimazeka kwe-renal, ngenkathi i-creatinine ivame ukubhekwa njengengajwayelekile kuma-75% wokulimazeka.
I-CYSC (CYSTATIN C) iyinhlangano ye-Cysteine Protease Invibitor, isisindo esiphansi samangqamuzana (13.3 kD), amaprotheni ayisisekelo angewona ama-glycosylated. Ingenye yezimpawu ezisetshenziswa kabanzi zomsebenzi wokuqala we-renal emithini yabantu. Njengo-Creatinine ne-SDMA, kuhlungwa nge-glomerulus, kepha kuhluke e-Creatinine nase-SDMA ngoba i-metabolism yayo ayisebenzi nge-retules ye-urines.It is a retbolism nge-revules.it yile mehluko acashile kodwa obalulekile onawo Akuzange kuqashelwe ngaphambili, kuholele izazi eziningi, ochwepheshe nezincwadi eziphethweni ezimbili ezihlukile ngokulimala kwezinso ezingapheli emakati: Abanye bakholelwa ukuthi i-Cysc ingumaki wokuqala wezinja namakati, kanti abanye bakholwa ukuthi i-CYSC Ixhumana kahle kahle ku-canine CKD, kodwa kabi ngamakati.
Kungani kuneziphetho ezimbili eziphikisanayo kusuka okufanayo"Inkomba yokusebenza kwe-filtration fieltration "?
IsizathuI-Anuria, okuyisimo esivame kakhulu Emakatikuna-in ezinye izinhlobo, ikakhulukazi emakati wesilisa. UshikukaziIdatha ye-ome ikhombisa ukuthi izehlakalo zeInturiaEmakati abesilisa aphezulu ngo-68.6%, ne-anuriangizo ngqoumphumela wokuvinjwa kweUkuchithwa kwe-creatinine,igaziUrea nitrogen ne-SDMA. TE-OrganiSmism ahlala ekhula futhi ekhiqiza i-creatinine entsha,igaziUrea nitrogen ne-SDMA,Lapho uthola konkeizinkomba ezintathu egaziningalesi sikhathi, kuzoba nokwanda okubukhali noma ngisho nokuqhuma kwezinkombaAkunandaba ukuthii-glomerulus is kulimele ngempela.
I-cyscinayoinani elihlukileNgalesi sikhathi, yizeLe nkomba ingukuhlunga kwe-glomerur,IkonaAKUFANELE WAHLULEKILE NGU-URINE,it is ngokusebenzisa i-tubularnge-reabsoloption. NiniI-Anuria yenzekaKepha umsebenzi we-renal ujwayelekile, inkomba ye-CYSC isengagcinwa ezingeni elijwayelekile. Kuphela lapho i-glomeruceleninoma ukulimala kwe-tubular kwenzeka ngempela,le khasiI-cyscinto ekhombayoizophakanyiswato okungajwayelekile. Ngakho-ke,ukutholwa kwakho konkeizinkomba ezintathu zingakwaziakhaukufakaza kahleosfuthi unikeze ukwelashwa okuhambisanayo ngokushesha okukhulu nangendlela efanele.
I-New-In-1 Test Kits inika ama-kits amasha emtholampilo ekutholeni ukulimala kwe-renal ezinjeni nasemakati!
Echazaizimiso nokuhlanganisange le khasiIzici zezinkomba, TheI-New-Test Renal Funct Marker 3-in-1 Test KitsWntshabalaazalwe ane-bonakalayoUkubaluleka KomtholampiloingomaneIzinja namakati (ikakhulukazi amakati)nge-anuria:
I-New-Test Renal Funct Marker 3-in-1 Test Kits bakhonawayevame ukwahlukanisa ukuthinakhuUkulimala komsebenzi we-real realesimweni se-anuriaor ImiphumelaUkuphakama kokuvinjelwa kwezinkomba ngenxa ye-anuria.Ukulimala kwe-real renal kudinga umchamo kuphelai-catheterization futhi okuhlobeneukuhlakanipha, futhi i-Prognosis ngokuvamile ingcono. Le khasiUkuphakama kokuvinjelwa kwezinkombaakudingi nje kuphelaumchazeloI-catheterization kanye nokwelashwa okulwa nokuvuvukala, kepha futhi nokwelashwa okuhlobene nesifo se-renal, kanye ne-prognosis kunzima kakhulu, futhi kungenzeka ukuthi baphenduke abe yisifo sezinso esingamahlalakhona.
Ngezansi kukhonale khasiUmsebenzi omusha wokuhlola we-renal marKer 3-in-1 testamaselaidatha ejwayelekileInturia(Okungeyona eyangempelaukulimala kwezinso) kanyeInturia+ Ukulimala kwezinsoekuhlolweni okusha-sesibhedlelaAmacala okucwaninga:
| Ukutholwa kwe-anuria I-New-Test Renal Funct Marker 3-in-1 Test Kits | Umklamo | Umphumela | Umphumela |
| I-Creatinine | + | + | |
| I-SDMA | + | + | |
| I-cysc | + | - | |
| Ukugcina | I-anuria iholele ekulimaleni kwe-renal | Isigaba sokuqala se-anuria kanye nokulimala kwe-renal noma i-auria engakafiki ukulimala kwe-renal |
Ngezansi kukhonaIngxenye ye-Clinical ejwayelekileidatha ne-Case Destription of theUmsebenzi we-renal wokuhlola omusha 3-in-1amasela:
| Ikati | Umlando Wezokwelapha | Uphawu lomtholampilo | I-CYSC (MG / L) | SDHA (UG / DL) | CR (MG / DL) | Ukugcina |
| 2024090902 | I-cystitis / ukulimala kwe-acute renal | Isimo esibi sengqondo, hlisa i-appetite, inkomba ye-renal engajwayelekile, i-anuria (ukwehluleka kwama-renal engapheli, i-anuria) | I-1.09 | 86.47 | 8.18 | Ukulimala kwe-renal nge-anuria |
| 2024091201 | / | Isimo esibi sengqondo, i-anuria, umsebenzi we-renal ongajwayelekile | 0.51 | 27.44 | 8.21 | Akukho ukulimala kwe-renal nge-anuria / isigaba sokuqala |
| 20240927002 | / | Inturia | 0.31 | > 100.00 | 9.04 | Akukho ukulimala kwe-renal nge-anuria / isigaba sokuqala |
| 2024103101 | / | Inturia | 0.3 | 14.11 | I-6.52 | Akukho ukulimala kwe-renal nge-anuria / isigaba sokuqala |
| 2024112712 | Inturia | 0.5 | > 100.00 | 8.85 | Akukho ukulimala kwe-renal nge-anuria / isigaba sokuqala | |
| 2024112601 | Dysuria / anuria | 0.43 | > 100.00 | 9.06 | Akukho ukulimala kwe-renal nge-anuria / isigaba sokuqala | |
| 0.47 | > 100.00 | 878 | Akukho ukulimala kwe-renal nge-anuria / isigaba sokuqala | |||
| 2024112712 | / | Inturia | 0.54 | 94.03 | 8.64 | Akukho ukulimala kwe-renal nge-anuria / isigaba sokuqala |
Esimweni se-anuria, ngenxa yeumehluko ngaphakathile khasiumshini wangaphakathi we-metabolicyenkomba ngayinye,Kuzoba nomphumela umehluko omkhulu werenal efanayosebenzaI-Filtration Index. Ngakho-ke,Ukuhlukaniswa okujwayelekile kweukulimala kwe-renalof I-Creatinine noma i-SDMA ayisasebenzi, futhi isiphetho soMtholampilo esiseduzane singatholakala kuphela ngokuhlanganisa ukuhlaziywa kwenye inkomba "CYSC".It Kunconywa ukuthi ama-laboratories (izibhedlela) asungule ngaphakathiamazingaNgokusekelwe kokuhlangenwe nakho komtholampilo, ukuze uhlole ukubaluleka kwemitholampilo eyengeziwe.
Ekugcineni, nI-EW-test biotechunxaneleloukuthi lesi sihloko sizokwenzalahla isitini ukuheha i-jade, futhi unethemba lokuthiIzidakamizwa Eziningi Zezilwane ZaseChinana-Abakhiqizi be-Reagreent Reagentisifisoukuthuthukisa imikhiqizo ebaluleke kakhulu emtholampilo futhi kusize okwengeziwe odokotela bezilwane zasekhaya ukuze bafinyelele ezingeni eliphezulu emhlabeni!
Isithasiselo: Ukwemukelwa kwesicelo se-patent sokuvikelwa kwempahla yengqondo
Isikhathi sePosi: Feb-12-2025
